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The positive ratio of -6/-3 PUFA, vitamins (E, B, C, and -carotene), fibers, minerals (selenium, iron, zinc, iodine) are key components of the MeD and account for its beneficial effects [15, 62, 121, 186]

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Microgliosis in the spinal cord is coordinated by sensory afferent derived injury signals, whereby chemokines, nucleotides, and other pro-inflammatory mediators released from damaged afferent terminals could signal through post-synaptic surface receptors to activate microglia