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The Stroke Prevention Trial in Sickle Cell Anemia (STOP), the follow-up STOP2, and the Silent Cerebral Infarct Transfusion (SIT) trial demonstrated that chronic transfusion reduces stroke risks (Ware et al., 2016)
None of these events change the appearance of the solution
Healthcare providers prescribe oral iron supplements first
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A 2026 crossover study in male cyclists found that oral rehydration produced faster time-trial performance, lower core temperature, and lower heart rate than IV saline during exercise in the heat
