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Trends Cell Biol 26(3):165176 Yang H, Zhuo JM, Chu J, Chinnici C, Pratic D (2010) Amelioration of the Alzheimers disease phenotype by absence of 12/15-lipoxygenase

These results suggest that a small fraction of dihexa undergoes enterohepatic recirculation, which could cause an increase in plasma levels

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Although global SIRT7 deficiency is known to cause systemic phenotypes such as cardiac hypertrophy and metabolic alterations, a VSMC-specific knockout model circumvented these systemic confounders, revealing a direct protective role of SIRT7 in vascular remodeling

T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity