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Common Adverse Effects The most frequently reported complications include: Abdominal pain and cramping: Often severe and requiring medical attention Rectal burning and irritation: The coffee solution can damage delicate rectal and colonic tissue Bloody stools: Indicating intestinal injury or inflammation Proctocolitis: Inflammation of the rectum and colon lining that can become chronic Electrolyte imbalances: Particularly dangerous depletion of sodium and potassium Dehydration: From excessive fluid loss and electrolyte disturbances Life-Threatening Complications Most alarming are the documented fatalities associated with coffee enemas

These findings suggest that optimal NAMPT levels and activity are critical for healthy aging and overall organismal homeostasis, and both upregulation and targeted inhibition may offer potential interventions depending on the specific context and tissue

Sources American College of Nutrition (2023) American Academy of Family Physicians (2022) National Institutes of Health (NIH, 2023) Interested in This Treatment

Jansen J, De Napoli IE, Fedecostante M et al (2015) Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations