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Liability 2: Significant CYP3A4 interactions increase comedication toxicity

(2002) The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

Research shows that when PARP1 depletes cellular NAD+, it disrupts the NAD+/SIRT1 system, which leads to faulty DNA repair and reduced cell survival

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All efforts were made to minimize suffering and to reduce the number of animals used

The EMBO journal, 30(10), 18851895
