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Ezraty et al., 2017)

The instrument was initially based on a twofactor model encompassing pain intensity and pain interference with daily functioning, using the patient's experience over the preceding week as the reference period

Hua X, Miller ZA, Wu G, Shi Y, Lodish HF

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For example, extracellular proteases, such as HGFA, matriptase, and MMP-2, can cleave and transform HGFs into their active biological state, thereby facilitating the release of HGF [55]

because rigorously controlled human safety data specific to the TB-500 fragment does not exist, its longer-term risk profile, including possible immune reactions, remains unknown Evidence snapshot: Evidence for TB-500 itself is preclinical, drawn mainly from cell-culture and animal studies (a 1999 rat wound-healing study and later rodent cardiac- and tendon-injury models), with a 2026 scoping review describing the musculoskeletal literature on thymosin beta-4 and TB-500 as sparse and largely preclinical