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Irisin also significantly alleviates tubular epithelial cell injury and fibrosis by inhibiting Smad3 phosphorylation and suppressing the expression of Nox4 (a downstream regulator of ferroptosis) in the UUO mouse model, thus blocking Smad3-mediated ferroptosis (202)

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These PAMs enhance the function of GluN1/GluN2A diheteromers or GluN1/GluN2A/GluN2B triheteromers, which are the predominant species of NMDARs located at the synaptic cleft in mature neurons [133]

Antioxidant status in relation to heavy metals induced oxidative stress in patients with polycystic ovarian syndrome (PCOS)

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KB serve as an efficient mitochondrial fuel, where it can alter the NAD+/NADH and Q/QH2 couples and reduce production of mitochondrial ROS