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Zhang J, He TH, Yin ZN, Shang CL, Xue LX, Guo HY

While optimal Zn levels confer protective benefits, such as improved insulin sensitivity and reduced oxidative stress, excessive intake triggers systemic inflammation, oxidative damage, and metabolic dysregulation

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Liu J, Yan L, Yang W et al (2019a) Controlled-release neurotensin-loaded silk fibroin dressings improve wound healing in diabetic rat model

Although trace metals such as iron and copper are essential for numerous physiological processes, their accumulation or dysregulation can lead to the generation of ROS, contributing to oxidative damage, lipid peroxidation, and impairment of both enzymatic and non-enzymatic antioxidant defenses [69]

If the goal is to study GH pulse architecture as it occurs physiologically (4 to 6 pulses per 24 hours, dominated by the slow-wave-sleep pulse), a short-acting GHRP fits the experimental design
