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doi: 10.1111/jpi.12547, 240

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The reactive species oxidize the different types of amino acids present in the protein and result in the generation of the protein-protein cross linkage which further results in the denaturation, loss of protein functioning, loss of transport protein and receptor functioning, and loss of enzymatic activity

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Pro-apoptotic proteins, including BAX and BAK, undergo conformational changes and oligomerize upon activation, leading to MOMP and cytochrome c release into the cytosol

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