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Description
Confronting stem cell hype Science 352 6287: 776-7
What did the studies show
Author contributions D-DW, S-MH, and Y-MW conceived and designed the study
Particularly in tumor cells with active glycolysis, accumulated lactate stabilizes and increases the activity of proglycolytic transcription factors such as HIF-1 and c-Myc, as well as the expression of their downstream target genes, via lactylation, thereby forming a self-reinforcing positive feedback loop that further entrenches the glycolytic phenotype of tumors [78, 79]
[DOI] [PubMed] [Google Scholar] 55.Matsubara T., Azums T., Yoshids S., Yamegami T
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