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Gross et al

Vitamin C enhances antioxidant activity while contributing to collagen synthesis and skin radiance

Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates

Another piece of evidence that intestinal oxygen dynamics plays a key role in ferroptosis-mediated microbe-host interactions is that the oxygen gradient established in the gut under physiological conditions is crucial for maintaining microbial ecological balance

In humans, the CYP450 enzyme that predominately catalyses the formation of NAPQI is CYP2E1, although in vitro CYP3A4, CYP2D6 and CYP1A2 have also been implicated in the formation of the toxic metabolite [18,19,20]

In contrast, the erastin-induced oxidative stress and cell death could be prevented in HT-1080 and other cancer cell lines by Trolox (a vitamin E analog), the iron chelator deferoxamine (DFO), the MEK inhibitor U0126, and the glutathione peroxidase mimetic ebselen