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A third TJ-independent pathway, the unrestricted pathway, occurs at sites of epithelial damage and does not have a size limit [16]

doi: 10.2174/187152808786848423

4447 MSCs promote neurogenesis 48 by releasing exosomes, producing numerous benefits such as reducing glial activation and brain A levels and improving cognition

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On the other hand, preclinical studies and clinical trials highlight the potent anti-inflammatory effects of TB-500 in various models of organ and tissue injury, including in the skin, eye cornea, liver, and central nervous system [34, 35, 38, 39]

Given the distinctive characteristics of PLA and PGA, functionalized PLGA nanoparticles can be favorably tailored by adjusting the PLA/PGA ratio, which in turn influences their overall hierarchical structure and physical stability as well as biodegradability (Cui et al., 2025), drug loading, and controlled release (Lim et al., 2022) (Figure 3E)