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Journal of Physiological Anthropology, 1 (14)

Note: Control group (150 min: n = 5

Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations

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In both control and BPM31510-treated MIA PaCa-2 and PANC1 cells, pyruvate (Complex I)-specific H 2 O 2 production was minimal, indicating that Complex I is an unlikely site for the exacerbated ROS production observed after BPM31510 treatment (Fig