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doi: 10.1210/jc.2015-1724 126 VerbanckMCanouilMLeloireADhenninVCoumoulXYengoLet al

582,583,584 Astrocytic changes in AD are complex, with disease stage and brain region specificity and include reactivity, degeneration and clasmatodendrotic death, and atrophy with loss of function

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The coefficients for the 2 treatment-by-time interaction terms represent the estimated difference in the 31 P-MRS measure between groups at week 1 and at week 12, adjusted for baseline values

For example, if you do not tolerate taking L-carnitine on an empty stomach well then consuming it with food can help with consistency