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That is the evidence gap in one sentence

Rawat P, Teodorof-Diedrich C, Spector SA

More Topography of the hydrophilic helices of membrane-inserted diphtheria toxin T domain: TH1-TH3 as a hydrophilic tether

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In addition, nanomedicine may help circumvent existing mechanisms responsible for the development of antibiotic resistance 8

Abstract It has been reported that Cu(II) ions in human blood are bound mainly to serum albumin (HSA), ceruloplasmin (CP), alpha-2-macroglobulin (2M) and His, however, data for 2M are very limited and the thermodynamics and kinetics of the copper distribution are not known