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10.1038/s41586-019-1705-2 8 Bosello-TravainV.ConradM.CozzaG.NegroA.QuartesanS.RossettoM.et al (2013)
Cancers 2018 , 10 (11) , 409

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149 These reactive species are able to induce DNA damage by the introduction of several modifications in bases and sugars, the generation of cross-linking between DNA and proteins, and the production of breaks in the DNA strand

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In the brain, the BBB and BCSFB serve crucial roles in maintaining the stability of physical and chemical elements in the brain tissue environment
