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We investigated the longstanding idea that the onset of psychotic symptoms in schizophrenia arises from an early phase of glutamate neurotoxicity, possibly related to loss of GABA restraint, oxidative stress or inflammation, that cumulatively results in a later phase of synaptic loss in keeping with magnetic resonance spectroscopy (MRS) evidence of reduced glutamate in schizophrenia, especially in older patients

At higher doses, side effects can be dangerous and life-threatening, such as seizures, loss of consciousness, depression of respiratory and circulatory centers, slow heart rate, and even cardiac arrest

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O objetivo de citar o mdico reconhecer e dar crdito aos exaustivos esforos de pesquisa e desenvolvimento conduzidos pelos cientistas que estudam este peptdeo