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Eur J Clin Invest 31:10071011

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Cytotoxic Mechanisms of NQO1 Bioactivating Compounds As stated in previous sections, NQO1 acts as a double-edged sword by playing crucial roles in cellular defense against oxidative stress induction by preventing the generation of ROS and at the same time catalyzing futile reductive cycles with certain quinones, leading to heightened redox stress in cancer cells

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These findings suggested that P-Mn/TI@mHSA modulated plaque macrophage activity, alleviated the inflammatory response, and subsequently inhibited the recruitment of additional immune cells, such as monocytes, to the plaque