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Herein, we systematically explore the well-documented ESCMs extracts or constituents with explicit anti-cancer properties, alongside their underlying mechanisms and pathways

100 To combat ICI resistance, studies are focusing on combination therapies targeting multiple immune pathways, including vaccines therapies

doi: 10.3389/fpsyt.2022.851679 Received 10 January 2022 Accepted 03 February 2022 Published 25 February 2022 Volume 13 - 2022 Edited by Maria Bove, University of Foggia, Italy Reviewed by Michelle Roche, National University of Ireland Galway, Ireland

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Oxidative stress also contributes to necrosis by damaging cell membranes through lipid peroxidation and exacerbating calcium dysregulation, leading to cell swelling and lysis (Munoz et al., 2017

Recent advances into the understanding of mitochondrial fission