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Epidemiology of Type 2 DiabetesGlobal Burden of Disease and Forecasted Trends

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NAD is essential for: Mitochondrial oxidative phosphorylation Sirtuin activity (especially SIRT1) DNA repair and cellular longevity In adipose tissue and certain cancers, high NNMT activity reduces NAD , impairing energy metabolism and promoting insulin resistance

Biol Chem 398(10):10951108

Aging naturally lowers production, while illnesses, infections, and certain medications speed up depletionmaking it vital to adopt habits that help preserve healthy levels

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