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A deficiency in either of these two enzymes caused by germline transmission of homozygous mutations can lead to a disease known as 2-hydroxyglutaric acidurias (2-HGA)
This, in turn, increases the intracellular concentration of glutathione (35, 56), making the cell more resistant to oxidative stress
Rev Esp Quimioter 37:299
P.GuW.QuK.et al
Erdman strain of M
