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Cell-mediated reduction of the interfragment disulfide in nicked diphtheria toxin

541,542 Alterations in T-cell behavior result in heightened proinflammatory TH1 and TH17 responses, reduced immune monitoring affecting the elimination of infected or cancerous cells, diminished self-tolerance contributing to autoimmune conditions, and weakened natural defenses, ultimately fostering widespread inflammation

MOG staining highlights the corpus callosum, in both (B) coronal and (D) sagittal slice cultures

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