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REF-0232 (v7.0) 1/2021

TPE is performed under the care of a licensed medical provider and monitored by healthcare professionals

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In fact, NO at high levels inhibits heme insertion in hemoglobin, NO synthases, and heme thiolate enzymes, such as cytochrome P450s (CYP) in different manners (i.e., through the direct binding to the heme iron or to covalent modifications in heme transfer proteins) [147,148,149]