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This limitation impacts the calculation of specificity for the combined biomarker and necessitates a cautious interpretation of the results

Li Y, Kang L, Rong K, Zhang Y, Suo Y, Yuan M

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doi: 10.3389/fcell.2021.813668 Received 12 November 2021 Accepted 31 December 2021 Published 20 January 2022 Volume 9 - 2021 Edited by Chunying Li, Fourth Military Medical University, China Reviewed by Takashi Matsui, University of Hawaii, United States Weinan Guo, Fourth Military Medical University, China Xin Wei, Second Hospital of Anhui Medical University, China Updates Copyright 2022 Leng, Luo, Yu, Jia and Yu

doi: 10.1016/s0014-2999(98)00038-7 105 VatterHSchillingLSchmiedekPEhrenreichH

Free heme can also occur in the circulation after erythrocyte hemolysis that results in the release of hemoglobin and heme, which can be bound by circulating haptoglobin and hemopexin, respectively [178]