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One-third of all drugs and drug candidates are excreted unchanged from the body by the kidneys, and drug-induced nephrotoxicity accounts for 20% of all episodes that lead to acute kidney failure (Naughton 2008b)
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Biomolecules 10 , 604 (2020)
Thus, through high consumption of NAD + , CD38 also indirectly impacts the activity of other NAD + -consuming enzymes such as sirtuins 52
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