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Further studies on the alkylation of nucleic acids and their constituent nucleotides

doi: 10.1016/s1532-0456(02)00126-6

Persistent low-grade inflammation can affect multiple organ systems, disrupt immune homeostasis, and ultimately contribute to progressive physiological decline [7]

Results and discussion Primary fragment screening by X-ray crystallography Due to its broad affinity detection range (nanomolar to millimolar) and unique ability to initiate rational drug design 30 , we carried out a crystallographic fragment screen against TRF1 TRFH at the XChem facility of the Diamond Light Source 30

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This creates two downstream problems: (1) SAM depletion reduces the availability of methyl groups for other critical methylation reactions, including DNA and histone methylation