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FIGURE 3 However, the limitation of passive targeting is that its targeting is relatively weak, and it is greatly affected by tumor heterogeneity and individual differences ( 2.2.2 Active targeting Active targeting, by contrast, modifies specific targeting molecules (such as antibodies, peptides, aptamers, etc.) on the surface of the nanocarriers so that they can accurately recognize and bind to specific antigens or receptors on the surface of tumor cells, thus achieving efficient drug delivery

Mice were divided into three treatment groups: control (saline), doxorubicin in non-modified PEGylated liposomes (Caelyx/Doxil), and doxorubicin GSH-modified PEGylated liposomes

Pre-fractionation increased peptide coverage and improved NAPQI-peptide discovery due to better resolution of peptides, thus reducing matrix effects in both MRM and DDA

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10.1016/j.redox.2015.06.005 [DOI] [PMC free article] [PubMed] [Google Scholar] Wernet P, Kunnus K, Josefsson I et al (2015) Orbital-specific mapping of the ligand exchange dynamics of Fe(CO)5 in solution