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Immunity 6 , 97105 (1997)

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Applying GHK-Cu or AHK-Cu immediately after microneedling delivers the peptide directly into the dermal layer where target cells reside

The metal-peptide complex can dissociate at elevated temperatures, releasing free copper and reducing efficacy
As far back as 2016, when BPC-157 started showing up as a potential doping problem, researchers had developed a method of detecting it at part-per-trillion levels in urine