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Long-term PPI use may also promote bile duct epithelial proliferation and bile duct epithelial micropapillary growth, resulting in focal bile duct stenosis and obstruction, which may also be associated with gallstone formation (Yang et al., 2020)

NICE-appraised licensed alternatives such as semaglutide (Wegovy) and liraglutide (Saxenda) are available through regulated UK weight management services

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This method provides site-specific information about structural changes
