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Haem, flavin and oxygen interactions in Hmp, a flavohaemoglobin from Escherichia coli
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The area becomes hollow in the inner corner of the eye, at the level of the lower eyelid and sometimes between the cheekbones and the nose (tear trough)

It should be emphasized that zinc binding to type 1 and type 5 sites also affects access to the 34-mer fragment 44-77 (contains Zn 2+ -coordinating Asp44), another crucial site of PEDF responsible for its anti-angiogenic activity 85 (Fig

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