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Some participants achieved weight loss of approximately 24% of body weight at 48 weeks approaching levels reported with some bariatric surgical procedures, though no direct head-to-head comparisons have been conducted and long-term durability beyond the trial period remains unknown

This may indicate a possible re-establishment of nitrogen balance, and a potential modification or enhancement of nitrogen levels in different tissues

NNMT is overexpressed in obese adipose tissue and is theorized to deplete SAM and NAD+ pools in adipocytes, contributing to metabolic dysfunction

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Ultimately, the journey of scientific discovery is built one precise step at a time

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