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Acknowledgements The work was supported by National Key R&D Program of China (2022YFC3400700), National Natural Science Foundation of China (22425404 and 92357308), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB39050700), Shanghai Key Laboratory of Aging Studies (19DZ2260400), Shanghai Municipal Science and Technology Major Project, and Shanghai Basic Research Pioneer Project

Reduced HGH levels are associated with: Increased visceral fat Reduced lean muscle mass Slower tissue repair Decreased sleep quality Lower metabolic efficiency This decline is part of normal aging but may be accelerated by chronic stress, poor sleep, and metabolic dysfunction

Our in vitro experiments on human primary monocytes show that the glutathione metabolism is involved in the regulation of the acute response to BDG at the transcriptomic and molecular levels, yet further studies are required to evaluate the functional impact of this phenomenon in vivo

Epigenetic inactivation of hydroxymethylglutaryl CoA synthase reduces ketogenesis and facilitates tumor cell motility in clear cell renal carcinoma

Unlike GnRH agonists that create an artificial menopause to suppress estrogen, the weight-mediated estrogen reduction through GLP-1 agonists is more physiological