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H 2 has antioxidant and anti-inflammatory effects, which can significantly alleviate diseases, such as ischemic brain injury, myocardial ischemiareperfusion injury, and sepsis-induced liver injury [142144]

The bifunctional enzyme inositol-requiring enzyme 1 (IRE1) exhibits both protein kinase and site-specific endoribonuclease activities, enabling XBP1 mRNA processing and targeted decay of ER-associated transcripts via Regulated IRE1-Dependent Decay (RIDD) ( In AT, obesity induces pronounced ER stress that fundamentally disrupts metabolic homeostasis through multiple tissue-specific mechanisms (102)

Fahrenholz T, Wolle MM, Kingston HMS, Faber S, Kern JC, Pamuku M, Miller L, Chatragadda H, Kogelnik A (2015) Molecular speciated isotope dilution mass spectrometric methods for accurate, reproducible and direct quantification of reduced, oxidized and total glutathione in biological samples

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2.5 Skin and hair health A study on skin health and one recently published study on hair quality have shown Pycnogenol s effects on beauty and skin health in RDP setups ( In a RDP study, Pycnogenol s effects on the skin of 78 urban outdoor workers was investigated ( supplementation for three months and only by 5% with placebo