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The V-CNT group received bilateral 30 L saline (0.9% NaCl), while the SUPP group received bilateral 0.65 mg cyanocobalamin (Sigma Aldrich 47869) dissolved in 30 L saline (0.9% NaCl), providing a total dose of 1.30 mg vitamin B12 per mouse per week for 12 weeks

In arriving at our criteria we consulted three standard textbooks of medicine (Alstead, Davidson and Price), a consultant haematologist, the librarian at the Royal College of General Practitioners, and the Monthly Index of Medical Specialities

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