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This study underscores the link between aging and LH-ALL, highlighting TP53-mutant clonal hematopoiesis as a potential preleukemic reservoir driving aneuploidy and the development of B-ALL in older adults

Nephron 143 , 154157 (2019)

Malignancy , 18

96,97 Moreover, the ME1 protein is hypophosphorylated at S336 and hyperacetylated at K337 by PGAM family member 5 and acetyl-CoA acetyltransferase, respectively, resulting in ME1 translocation from mitochondria to the cytosol, dimerization and activation, thus strongly promoting NADPH generation and tumorigenesis
It primarily arises from the catabolism of nutritional substrates such as phosphatidylcholine, choline, carnitine, betaine, dimethylglycine, and ergothioneine by the colonic microbiota (118)

The digestive system is where external contaminants are first encountered, and the kidneys play a crucial role in waste metabolism in the body
