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Some essential efflux transporters are Mdr-1 (P-glycoprotein), breast cancer resistance protein (BCRP), and multidrug resistance-associated proteins (MRPs) [6]
Researchers attribute this to three mechanisms studied in animals: the growth of new blood vessels (angiogenesis, via VEGFR2), the movement of repair cells to the injury (fibroblast migration, via the FAK-paxillin pathway), and effects on blood flow through the nitric-oxide pathway
doi: 10.1253/circj.cj-09-0692
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