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Several factors are established to affect the transduction signals of VEGF, which include P13K/AKT pathway during hypoxia conditions, RAS/RAF/MAPK (ERK) pathway during normoxia and probably via the activation of EGFR in non-hypoxia conditions

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[DOI] [PubMed] [Google Scholar] Hidalgo M., Rodriguez G., Kuhn J.G., Brown T., Weiss G., MacGovren J.P., Von Hoff D.D., Rowinsky E.K