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In mild-to-moderate allergic asthma, type 2 CD4 + lymphocytes (Th2 cells) and their cytokines predominate, whereas severe steroid-resistant asthma has a more mixed Th2/Th1 phenotype with a Th17 component

While physiological levels of ROS are required in the normal transition between wound healing phases, as previously described, an overproduction of ROS has deleterious effects and can hinder wound healing 159

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Additionally, in RECs, hyperglycemia further enhanced the binding of DNMT1 and TET2, amplifying MMP-9 activation and worsening mitochondrial dysfunction