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In rodents, exposure to a blast injury at 10.8 psi once per day for 3 days resulted in an accumulation of pathological tau aggregates in the brain (35)

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doi: 10.3390/ijms21144986

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And declining NAD levels are closely related to various metabolic issues, including fatty liver disease and diabetes

Helicobacter pylori in the pathogenesis of gastric cancer and gastric lymphoma