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Dosage should be adjusted flexibly according to the purpose of use, following the principle of gradual increment
Certain medications The following drugs can reduce levels of vitamin B12 in your body: Antibiotics -- long-term use can lower vitamin B levels generally Anti-seizure drugs Chemotherapy medicines, especially methotrexate Drugs used to reduce stomach acid, like H2 blockers (Pepcid AC, Tagamet, Zantac) and proton pump inhibitors (Nexium, Prevacid, Prilosec) Metformin (Glucophage) -- taken for diabetes Colchicine -- taken for gout Some cholesterol-lowering medications Other causes You're over 65

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And I have been a personal trainer for 24 yrs
The most common side effects are fatigue a day or two after you take methotrexate, which is why I suggest taking it at night, he says
