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[DOI] [PMC free article] [PubMed] [Google Scholar] 100.Giacco F, and Brownlee M

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thus although more AST is released from the liver, the much longer half-life of ALT leads to higher activities of ALT than AST in most forms of hepatocellular injury

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In this context, it seems that the available animal CIPN models are manifestations of gain in sensory functions which measure mainly allodynia, hyperalgesia and neurophysiological alterations in nerve function, whereas many patients, at least in the chronic phase of CIPN also report other symptoms, such as numbness, tingling and ongoing pain

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