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FIGURE 6 In summary, GPX7 is an essential sensor for oxidative stress and endoplasmic reticulum stress ( 2.8 GPX8 Glutathione peroxidase 8 (GPX8) is a type II transmembrane protein with rare structural features that consists of 209 amino acids ( 2+ storage and histamine-induced Ca 2+ release in the endoplasmic reticulum ( 2+ levels in the endoplasmic reticulum ( 2+ from the endoplasmic reticulum to mitochondria and cytoplasm is increased ( 2+ may be related to the inositol 1,4,5-triphosphate receptor (IP3R) effect, and the transmembrane domain (TMD) of GPX8 is thought to play a key role in the regulation of Ca 2+ signaling ( 2+ in the endoplasmic reticulum

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[164] Therefore, high concentrations of dehydroascorbic acid derived from vitamin C might inhibit glucose uptake into cancer cells and therefore hinder cancer cell fuel utilization needed for survival and growth