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Pathophysiology beyond dopaminergic neuronal loss The alpha-synuclein model Alpha-synuclein is a presynaptic neuronal protein whose abnormal aggregation into Lewy bodies leads to disruption in cellular homeostasis and consequently neurodegeneration 7

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Can J Infect Dis Med Microbiol 2023:6981721 Schoeler M, Caesar R (2019) Dietary lipids, gut microbiota and lipid metabolism

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Consequent to the inhibition of the NF-B pathway, both -SMA expression of PSC and ECM deposition were downregulated

This patient's intact, albeit abnormally positioned, feet and the history of oligohydramnios-induced compression make a disruption unlikely