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The disturbance of the gut microbiota occurs in a variety of diseases, including infections and sepsis (79)

However, when the level of long-chain acylcarnitines (LCACs) is abnormally elevated, not only is it a signal of mitochondrial dysfunction but its high concentration can also aggravate mitochondrial damage and further deteriorate mitochondrial function [20, 21]

Data analysis was conducted based on both per-protocol and intention-to-treat (ITT) approaches ( t -test was used for numerical variables, while the Pearson chi-square or the trend chi-square test was used for categorical variables

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Pettegrew, J

Data availability The datasets analyzed during the current study are available from the corresponding author on reasonable request