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Abstract Heme, the protoporphyrin IX iron complex is widely present in the human body and it is involved in oxygen storage, electron transfer, and enzymatic reactions

In this context, the application of advanced in vitro models, such as three-dimensional (3D) cell cultures and organ-on-chip systems, deserves particular attention

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Prescription-strength formulations may offer faster results but require medical supervision to prevent side effects

However, the protective subsets of NEUs, alongside their reparative cytokines, demonstrate their functional duality

This is especially significant when people are taking multiple pharmaceuticals that may be liver toxic and have a cumulative effect