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They serve as coenzymes in numerous biochemical reactions

Ethics declarations Ethics approval This study was performed in line with the principles of the Declaration of Helsinki

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request

While the analysis of the entire PD cohort (including de novo patients and treated patients) in addition to the de novo patient-specific analysis allowed us to maximize statistical power to detect PD-associated changes, we also performed a dedicated analysis for treated patients only, using the same filtering and adjustment steps as for the entire PD dataset, to better distinguish changes in treated from treatment-nave patients

We also recommend limiting gum chewing and foods that require prolonged chewing, as these can overtax already strained muscles