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The import of cystine by xCT has been at the forefront of many cysteine metabolism studies in cancer cells as many cancers, including glioblastoma, triple-negative breast cancer, and non-small cell lung cancer, overexpress and use xCT for cystine uptake [22,26,27,28,29,34]

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The assay revealed however also a higher potency for SFN than for AITC, which might be due to differences in physicochemical properties such as their ability to cross the cell membrane, compound stability or differences in reactivity

Capillaries narrow or disappear entirely
