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May also increase bleeding when taken with blood thinners and intensify cardiovascular symptoms such as high blood pressure , angina, and atherosclerotic plaques

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doi:10.1161/STROKEAHA.107.504498

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Early animal and small human studies suggest it is generally well tolerated in the short term, but we do not yet have large, longterm trials
The AOD9604 safety profile shows no significant adverse effects on liver enzymes, kidney function, or cardiovascular parameters in clinical studies
