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Clioquinol inhibits dopamine--hydroxylase secretion and noradrenaline synthesis by affecting the redox status of ATOX1 and copper transport in human neuroblastoma SH-SY5Y cells
Treatment also reduced astrocyte activation at 7 days post-injury and lesion volume at 28 days post-injury (112)

Inhibition of TLGST with the metal chelating agent EDTA suggested it as a metalloenzyme

Initiating treatment at a low dose with a gradual increase, if needed, can enhance patient adherence, and reduce the risk of side effects expected with maximum dosage

Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit

& Coloff, J
