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Clioquinol inhibits dopamine--hydroxylase secretion and noradrenaline synthesis by affecting the redox status of ATOX1 and copper transport in human neuroblastoma SH-SY5Y cells

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Treatment also reduced astrocyte activation at 7 days post-injury and lesion volume at 28 days post-injury (112)

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Inhibition of TLGST with the metal chelating agent EDTA suggested it as a metalloenzyme

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Initiating treatment at a low dose with a gradual increase, if needed, can enhance patient adherence, and reduce the risk of side effects expected with maximum dosage

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Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit

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& Coloff, J

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