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sdAb 2F8 can be radiolabeled with 99m Tc, 111 In and 177 Lu to perform biodistribution studies and evaluate therapeutic efficacy in murine xenograft models

During treatment, repeat biomarker testing at 812 weeks helps confirm that injections are raising B12 status and reducing metabolic markers

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Thus, many patients have been told they are not B12 deficient but never had their actual levels assessed

Passive diffusion allows roughly 1% to 2% of a massive oral dose to be absorbed directly across the mucosal lining, completely bypassing the need for stomach acid or Intrinsic Factor